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The Exercise Pill Friday, September 19, 2008 - Anni Shaer Levitt Home >> News >> Medicine   
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If you don't like exercising you're definitely not alone in your aversion. However, soon there may be a solution for you – in a form of a pill. Scientists from the Salk institute for Biological studies in California have developed a drug that imitates the effect on exercise on the body. This discovery can have great implications for patients with muscle diseases such as wasting and frailty, as well as obesity and for the many associated metabolic disorders where exercise is known to be beneficial but physically difficult to perform.
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Previous findings of the research team have shown that a permanent activation of the PPAR delta type receptor makes mice endure physical strain for long periods of time. The examined mice were also resistant to weight gain, even when put on a high-fat diet which causes obesity in ordinary mice. Another health benefit the mice exhibited was an improved response to insulin, which lowered levels of circulating glucose. The next step was to test whether it was possible to activate this genetic pathway by use of a drug, as genetic engineering in humans is still not practical. The drug used is called GW1516 and was given to mice in the course of four weeks. Contrary to what was expected, the team found the mice showed no decrease in fatty acids and blood glucose levels. Surprised, the researchers then put the mice to a training program, having them run on a treadmill for 50 minutes daily. Suddenly, a vast improvement was shown. Endurance was improved by 77% and the portion of "non-fatiguing" or "slow twitch" muscle fibers rose by 38 percent.
During the next stage of the experiment the researchers gave mice AICAR, a synthetic AMP analog which activates AMPK. The mice were put through no training and after four weeks of simply taking the drug, the group showed 44% greater endurance than untreated, untrained mice, which is similar to improvement caused by four week exercise. Although these results may sound tempting to all couch potatoes, it is doubtful that this drug will be released soon to the market for mass use. A test for these drugs is also being developed in collaboration with World Anti-Doping Association, so if you're a sports contender seeking undetectable doping drugs, this is not the right solution for you. Yet the knowledge gained from the experiments may help in the development of drugs to help various muscle diseases such as wasting and frailty. TFOF has recently covered a story on weight management telling of a gene involved in weight gain discovered by scientists from the London School of Medicine. Another story recently covered by TFOT river gym which is propelled by workout, designed by architect Mitchell Joachim. More information on the exercise pill can be found on the Salk Institute for Biological Studies’ website. |
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ok, I have muscular atrophy and i am 15 years old but i was wondering if i could take theese pills and witch would be their secondary effects because im really exited if they could help, thx |
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It sounds like this drug could kill the bypass industry and help a lot of people with muscular and insulin problems. I am wondering if this could be used as a "booster" for normal overweight people to get them lean and muscular within a relatively short period of time. Many people cannot run due to the damage to their feet because they are so overweight. Perhaps a few months on this treatment could get them to a state where they could resume a normal "active" lifestyle. Sounds promising. |
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| where is this selling? I want to buy it! | |||
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i dont think that this is will work. Its probably fake, even though i really want it. |
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| i def. want this and need this!! where can i buy!!!! | |||
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| to good to be tru |
