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Tiny Rifts Create Fragility of Brittle Bones Wednesday, August 05, 2009 - Anuradha Menon Home >> Headlines >> Medicine   
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The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon. According to researchers at MIT, that minuscule encoding error creates a defective collagen molecule that, at the site of the amino acid substitution. (source: web.mit.edu)
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